When running Xfce system, the user's mouse or keyboard doesn't get any response
From Terasic Wiki
1) Because the USB gadget function is enable by default in the Xfce system, any extral USB device needs to be connected to the DE10-Nano AFTER the Xfce boots up. Otherwise the extral USB device will not be detected by the system. For how to enable/disable USB gadget function in the Xfce system, please refer to DE10-Nano Getting_Started_Guide.pdf, section 6.4.
2) Some USB mouse or keyboard may have compatibility problem with Xfce system, if user's mouse or keyboard doesn't get any response in the Xfce system, please re-plug the USB cable or change other brand's USB mouse or keyboard.